Single-step Electrospinning of Bioactive Polymer Nanofibers

Macromolecules of Raffi Gentsch accepted
Polymer nanofiber meshes that possess biofunctional peptide segments on their surfaces are obtained with a standard electrospinning setup. Spinning a homogeneous mixture composed of a valuable polymer-peptide conjugate and a biocompatible commodity poly(ester) leads to nonwovens where the peptide part is enriched up to 11-times on the fiber surface. Bioavailability and bioactivity of the peptides are demonstrated as the meshes promote adhesion and migration of fibroblasts.