(Bio)Molecular Surface Patterning by Phototriggered Oxime Ligation

Thomas Pauloehrl, Dr. Guillaume Delaittre, Dr. Michael Bruns, Maria Meißler, Prof. Dr. Hans G. Börner, Prof. Dr. Martin Bastmeyer, Prof. Dr. Christopher Barner-Kowollik.

Making light work of ligation: A novel method utilizes light for oxime ligation chemistry. A quantitative, low-energy photodeprotection generates aldehyde which subsequently reacts with aminooxy moieties. The spatial control allows patterning on surfaces (see scheme) with a fluoro marker and GRGSGR peptide and can be imaged by time-of-flight secondary-ion mass spectrometry.