Regulating hierarchical nanostructure formation in bioconjugates via calcium ions

Paper published in Angew. Chem. Int. Ed. Inter- and intramolecular Coulomb interactions of peptides are modulated leading to a biomimetic approach to reversibly regulate functions in peptide-polymer conjugates. As triggers to screen peptide charges and thereby switching the peptide secondary structure, calcium ions are exploited. This results in a reversible control mechanism for bioconjugate self-assembly. By regulating the Ca2+ levels using competitive Ca2+ binders disassembly is feasible.

ACIEE: DOI: 10.1002/anie.201100141