News

03.01.2017 - Inhibition of Tau protein aggregation by rhodanine-based compounds solubilized via specific formulation additives to improve bioavailability and cell viability

New Paper in Current Alzheimer Research has been published.


Background: Anti-aggregation drugs play an important role in therapeutic approaches for Alzheimer’s disease. We have previously developed a number of compounds that are able to inhibit the pathological aggregation of Tau protein. One common obstacle to application is the limited penetration across the plasma membranes into cells, where Tau aggregation occurs in the cytosol. We used an inducible N2a cell line which expresses the repeat domain of tau and develops tau aggregates.
12.12.2016 - Easy access to triazolinedione-endcapped peptides for chemical ligation
New Paper in Chemical Communications has been published
A triazolinedione-precursor is directly built up from N-terminal peptide amine on resin enabling a versatile route towards peptide-polymer conjugates.
 

doi: 10.1039/c6cc08683g

06.12.2016 - SALSA Poster Session
Carmen Juds was rewarded the poster award of the SALSA Poster Session 2016. Congratulations!

The annual poster session of the School of Analytical Sciences Adlershof took place at the chemistry institute (Campus Adlershof) on December 6th, 2016. In the course of this event, Mrs. Carmen Juds won a poster award. Congratulations! (link)
14.10.2016 - Chapter 1: Synthetic Aspects of Peptide- and Protein-Polymer Conjugates in the Post-click Era.

New book chapter in RSC Polymer Chemistry Series No. 22: Bio-inspired Polymers has been published.


 
 
This book chapter will provide an insight into the chemical synthesis of peptide- and protein-polymer conjugates, ranging from classical synthetic reactions, to efficient bioorthogonal strategies, novel bioconjugation techniques and chemoenzymatic approaches. Against the background of bio-inspiration, the book will give a comprehensive review of novel polymer synthesis, adaptive composites and bio-mimetic surfaces. Diverse applications of bio-inspired polymers in fields such as tissue engineering, drug delivery, optical materials and many more are described.

 
doi: 10.1039/9781782626664-00001

01.08.2016 - Advancing Drug Formulation Additives toward Precision Additives with Release Mediating Peptide Interlayer

New Paper in Journal of the American Chemical Society has been published


 

doi: 10.1021/jacs.6b03604

04.06.2016 - Easy Access toward Functional Patterns on Cellulose Paper by Combining Laser Printing and Material-Specific Peptide Adsorption

New Paper in Angewandte Chemie has been published

 
Stick to print: Selective coating of laser-printed patterns was achieved by material-specific adhesion of peptides to cellulose or toner. The peptide sequences were obtained using phage display. Functionalization of the immobilized peptides was realized by selective modification of tyrosine residues present on the printed-pattern coatings, offering new ways towards low-cost printed devices.

doi: 10.1002/anie.201601603
19.04.2016 - Enzyme-triggered antifouling coatings: switching bioconjugate adsorption via proteolytically cleavable interfering domains.

New paper in ACS Macro Letters has been published.


 

The enzymatic activation of non-adhesive peptide-polymer conjugates by proteoytic cleavage of suitable interfering domains results in stable surface coatings. An efficient reduction of protein/surface interactions is shown.

doi: 10.1021/acsmacrolett.6b00072
 

12.06.2015 - 4th International Conference

Felix Hanßke was rewarded a poster award. Congratulations!

From June 10 to 12, 2015 The 4th International Conference "Strategies in Tissue Engineering" of WITE e.V. took place at the Congress Center Würzburg. In the course of this event, Mr. Felix Hanßke won the poster award for the best “materials” poster. Congratulations! (link)
 

08.06.2015 - Generic biocombinatorial strategy to select tailor-made stabilizers for sol-gel nanoparticle synthesis.
New Paper in Small has been published.
 
A generic route toward de novo design of tailor-made stabilizers for sol-gel nanoparticle synthesis is described. By exploiting phage display biopanning to select stabilizers from large peptide libraries, a significantly larger chemical space (~ 109 different compounds) is explored, compared to commonly used knowledge-based or empiric strategies. The approach is demonstrated on the fluorolytic sol-gel synthesis of MgF2 nanoparticles from Mg(OCH3)2 precursors. Peptide sequences are selected, showing sequence-specific adsorption onto MgF2 particle surfaces.

doi: 10.1002/smll.201500162
 
05.05.2015 - School of Analytical Sciences Adlershof (SALSA) Poster Session 2015

Valeria Samsoninkova was rewarded the SALSA “Best Design” Poster award 2015. Congratulations! (link)
09.04.2015 - 4. Berliner Chemie Symposium (BCS)

Felix Hanßke was rewarded the poster award of the BCS/EYCN Meeting 2015. Congratulations!

The 4rd Berliner Chemie Symposium (BCS) together with the annual European Young Chemists Network (EYCN) meeting took place at the Erwin Schrödinger Zentrum (Campus Adlershof) on April 9th, 2015. In the course of this event, Mr. Felix Hanßke won a poster award. Congratulations! (link)


19.03.2015 - Synthesis of conjugates combining macromolecular brushes and rigid macrocycles.

New Paper in Polymer has been published.
 
On the occasion of the 65th birthday of Krzysztof Matyjaszewski (Link) a synthesis route to a conjugate comprised of two macromolecular brushes and a central shape persistent macrocycle utilizing ATRP is presented. As a result of the properties of the combined structure elements a functional macromolecule is obtained that regulates accessibility to a central shape persistent macrocycle via reversible brush-coil transitions.

doi:10.1016/j.polymer.2015.02.059
19.11.2014 - Forum Junge Spitzenforscher: New Materials - Award

Patrick Wilke received:

Innovation award 2014 from Humboldt Innovation in collaboration with Stiftung Industrieforschung for the presentation “Ein biokombinatorischer Ansatz zu aktivierbaren, muschelinspirierten Adhäsiven”.


01.09.2014 - A direct biocombinatorial strategy towards next generation, mussel-glue inspired saltwater adhesives.
New Paper in Journal of the American Chemical Society has been published.
 
Biological materials exhibit remarkable, purpose-adapted properties that provide source of inspiration for designing new materials to meet the requirements of future applications. For instance, marine mussels are able to attach to a broad spectrum of hard surfaces under hostile conditions. Controlling wet-adhesion of synthetic macromolecules by analogue processes promises to strongly impact materials sciences by offering advanced coatings, adhesives and glues.



01.09.2014 - Revealing the impact of poly(ethylene oxide) blocks on enzyme activable coatings from peptide-polymer conjugates
New Paper in European Polymer Journal has been published.
 
Peptide-polymer conjugates composed of a poly(ethylene oxide) (PEO) block and a precursor segment from mussel foot protein-1 (mefp-1) are enzymatically oxidized by tyrosinase. A functional transition from weak/reversible binders to strong/irreversible adsorption onto aluminum oxide surfaces is observed. To elucidate effects of PEO-block length on the enzyme activable formation of antifouling coatings on aluminum oxide surfaces, a set of mefp-1-block-PEO bioconjugates with PEO-block lengths of 850, 3200 and 5200 g/mol is synthesized and investigated.


28.08.2014 - Hans Börner and Stefan Hecht (Humboldt-Universität zu Berlin, Berlin) organized the 2nd ERC-Grantees Conference on „Frontiers in Chemistry - The Basis for Advanced Materials“


It is our great pleasure to invite you the 2nd European meeting of ERC grantees in chemistry to be held in Berlin on August 28 & 29, 2014. The meeting Frontiers of Chemistry continues a tradition started in Strasbourg two years ago.
The aim of the conference is to gather some of the leading European experts in the field of chemical materials research, showcase their latest achievements, and discuss about future trends.

Weblink

 


25.05.2014 - J.-F. Lutz (Institut Charles Sadron, UPR22 CNRS, Strasbourg) and H. G. Börner (Humboldt-Universität zu Berlin, Berlin) organized the EUPOC 2014 on precision polymers.



The objective of this conference will be to discuss a new side of macromolecular research: “Precision Polymers”. In particular, this conference will highlight new directions in polymer synthesis. Indeed, we believe that the polymer chemists of the 21st century have to explore options, which are beyond conventional macromolecular engineering. For instance, the control over polymer architectures is nowadays not a challenge anymore. Recent tools such as controlled radical polymerizations or “click” chemistry allow a fine control of polymer architectures.

Weblink



15.05.2014 - Congratulations to Prof. Dr. Laura Hartmann


Congratulations to Laura Hartmann, who successfully defended her habilitation at the FU-Berlin and received a call to the W3 professor position at Heinrich Heine University of Düsseldorf (Nachfolge Ritter). We are very happy about the first academic offspring from the Börner Lab as Laura achieved her Ph.D. with us from 2004 to 2007.

Weblink

09.04.2014 - 3. Berliner Chemie Symposium (BCS)

Steffi Große was rewarded the poster award of the BCS 2014. Congratulations!

The 3rd Berliner Chemie Symposium (BCS) took place at the Erwin Schrödinger Zentrum (Campus Adlershof) on April 9th, 2014. In the course of this event, Ms. Steffi Große won a poster award. Congratulations! (link)


05.12.2013 - Complex Single-chain Polymer Topologies locked by Positionable Twin Disulfide Cyclic Bridges
New Paper published in collaboration with Jean-François Lutz.

Oligomers containing the peptide sequence cysteine-anycysteine (CXC) were attached, at specific locations, to a linear chain of polystyrene. The polymer-bound peptide motifs were then oxidized in dilute conditions to afford a complex bio hybrid bi-cyclic topology via intramolecular twin disulfide bridge formation.

 
PDF


28.10.2013 - School of Analytical Sciences Adlershof
2nd SALSA doctoral project call

"Revealing secrets of material specific peptide adhesion: From advanced NMR analysis to computational process modeling"

Promotionsstelle Börner - Ausschreibung
24.07.2013 - Spatially Controlled Surface Immobilization of Nonmodified Peptides
New Paper published in collaboration with Christopher Barner-Kowollik (KIT).

A phencyclone derivative is used to achieve light-controlled immobilization of peptides possessing only natural amino acids. The photoactive precursor (blue in picture) is formed in a Diels–Alder reaction and can undergo light-triggered ring-opening reactions with amines. Successful surface patterning with a genuine c(RGDfK) peptide (green) is evidenced by imaging time-of-flight secondary-ion mass spectrometry (ToF-SIMS).

PDF



12.07.2013 - Convenient Routes to Efficiently N-PEGylated Peptides
New Paper published in collaboration with Jean-François Lutz.

Efficient routes to N-terminal PEGylated peptides are described. Alternative supports such as superparamagnetic core–shell nanoparticles as colloidal supports and end-functional poly(styrene) as homogeneous supports improve the available solid-phase supported coupling strategies preserving ease of purification. Poly(ethylene glycol) (PEG)–peptide bioconjugates are obtained in high yield despite the use of nearly stoichiometric PEGylation agents with respect to the supported peptides.
 
PDF




11.01.2013 - Exploiting Specific Interactions toward Next-Generation Polymeric Drug Transporters
New Paper in Journal of the American Chemical Society has been published.

A generic method describes advanced tailoring of polymer drug carriers based on polymer-block-peptides. Combinatorial means are used to select suitable peptide segments to specifically complex small-molecule drugs. The resulting specific drug formulation agents render insoluble drugs water-soluble and enable precise adjustment of drug-release profiles beyond established block-copolymer carriers.

  PDF


13.08.2012 - (Bio)Molecular Surface Patterning by Phototriggered Oxime Ligation
New Paper published in collaboration with Christopher Barner-Kowollik (KIT).

Making light work of ligation: A novel method utilizes light for oxime ligation chemistry. A quantitative, low-energy photodeprotection generates aldehyde which subsequently reacts with aminooxy moieties. The spatial control allows patterning on surfaces (see scheme) with a fluoro marker and GRGSGR peptide and can be imaged by time-of-flight secondary-ion mass spectrometry.

English PDF                   German PDF


26.06.2012 - Mussel-Glue Derived Peptide–Polymer Conjugates to Realize Enzyme-Activated Antifouling Coatings
New Paper in ACS Macro Letters has been published.

Enzyme activated polymer coatings based on peptide-polymer conjugates are described. Tyrosinase is used to “switch on” adhesive functions of a mussel glue derived peptide segment, leading to bioconjugates that adhere to steel. The coating resists seawater treatments and modulates surface properties to anti-fouling surfaces by strongly reducing protein adsorption.

PDF
 


13.06.2012 - Superparamagnetic core-shell nanoparticles as solid supports for peptide synthesis
New Paper in Chem. Commun. has been published.

Magnetite nanoparticles are coated with a silica-shell and functionalized with amino groups to further introduce linkers moieties needed for peptide synthesis. The size of the colloidal supports of ~70 nm allows chemical peptide synthesis in “quasi solution”. An external magnetic field is used for magnetic sedimentation for ease of purification of the products after each reaction step.

PDF


08.05.2012 - Zimmer Award 2012
Hans Börner received:
International Hans and Marlies Zimmer Award 2012
from the University of Cincinnati, USA.
03.04.2012 - 2. Berliner Chemie Symposium (BCS) - AWARDS

2nd Berliner Chemie Symposium (BCS)

Patrick Wilke: Price for the second best Lecture held
Sebastian Wieczorek: Price for the best Poster submitted                               Congratulations!

 
              
12.03.2012 - ‘‘Inverse’’ synthesis of polymer bioconjugates using soluble supports
Paper published in Chem. Commun. together with Dr. Jean-Francois Lutz (Strasbourg).

Well-defined cleavable or non-cleavable soluble polystyrene supports were prepared by atom transfer radical polymerization and utilized for the iterative synthesis of functional hexapeptides. This approach allowed rapid and efficient liquid phase synthesis of peptide–polymer conjugates.

PDF
 
23.12.2011 - Peptide-mediated nanoengineering of inorganic particle surfaces: A general route toward surface functionalization via peptide adhesion domains.
New Paper in JACS has been accepted.

A one-step surface coating procedure is described. Coating is performed with peptide adhesion domains, found via phage display. This highly generalizable protocol permits various surface functionalization, which was shown by introduction of a fluorescent dye and PEGylation on Gadolinium oxide particles.

Manuscript ID: ja2104944; Journal of the American Chemical Society (JACS)
 



09.12.2011 - Adding Spatial Control to Click Chemistry: Photo triggered Diels–Alder Surface (Bio)functionalization at Ambient Temperature
New Paper published in collaboration with Christopher Barner-Kowollik (KIT)

A photoconjugation strategy based on light-triggered Diels–Alder addition of o-quinodimethanes is described. The method provides spatial control, is compatible with biomolecules, and proceeds rapidly at ambient temperature without the need of a catalyst.

DOI: 10.1002/anie.201107095, Angew. Chem. Intern. Ed. 2012
 



09.08.2011 - Self-assembling nanofibers from thiophene-peptide diblock oligomers: a combined experimental and computer simulations study
Paper in ACSNano has been accepted 08.08.2011

Bioconjugates combining PEO-functionalized peptide segments with covalently linked semiconducting alkylated quaterthiophene moieties are reported. Self-assembly and stimuli-responsiveness was investigated in a convergent experimental and computational approach.

 



13.07.2011 - Berliner Tag der Chemie im Jahr der Chemie @ HU-Berlin

Der “Tag der Chemie” der Berliner Universitäten wird unter der Organisation des AK Börners an der HU-Berlin veranstaltet. Das diesjährige Motto “Studium....und dann?” soll zum Informationsaustausch zwischen Industrie und Universitäten anregen. Ausgewählte Beiträge beleuchten das Thema aus Sichtweisen namhafter Industrieunternehmen, Mittelständiger Unternehmen und Nachwuchsgruppen.

http://www.nordostchemie.de/tdc/tdc-tag-der-chemie


 
15.06.2011 - A book was published on Bioactive surfaces

Börner and Lutz edited a book on the topic of Bioactive Surfaces in the series of Advances in Polymer Science.

Börner, H. G.; Lutz, J.-F., (Eds.), "Bioactive Surfaces" In: Advances in Polymer Science,. Springer-Verlag: Berlin, Heidelberg, New York, 2011; Vol. 240.
 
26.05.2011 - Calcium ions as bioinspired triggers to reversibly control the coil to helix transition in peptide-polymer conjugates

Paper to be published in Soft Matter A de novo designed calcium responsive peptide sequence was synthesized and the effect of conjugating poly (ethylene oxide) of different molecular weights on the calcium induced coil-to-helix transition was investigated. The secondary structure transition showed to be reversible upon addition of competitive calcium ion binders.

Soft Matter, DOI:10.1039/C1SM05625E
 
08.04.2011 - Regulating hierarchical nanostructure formation in bioconjugates via calcium ions

Paper published in Angew. Chem. Int. Ed. Inter- and intramolecular Coulomb interactions of peptides are modulated leading to a biomimetic approach to reversibly regulate functions in peptide-polymer conjugates. As triggers to screen peptide charges and thereby switching the peptide secondary structure, calcium ions are exploited. This results in a reversible control mechanism for bioconjugate self-assembly. By regulating the Ca2+ levels using competitive Ca2+ binders disassembly is feasible.

ACIEE: DOI: 10.1002/anie.201100141
 
21.01.2011 - Watchmakers in Polymer Science – On the Road to Precision Macromolecular Chemistry

Special Issue published in Macromol. Rapid Commun. (vol. 32, issue 2, 2011) Guest-editors: Hans G. Börner (Humboldt-Universität zu Berlin) and Jean-Francois Lutz (Institut Charles Sadron, Strasbourg)

http://www.materialsviews.com/details/news/980719
 
19.01.2011 - Precision Polymers — Modern Tools to Understand and Program Macromolecular Interactions
Paper published in Macromol. Rapid Commun. 2011, 32, 115-126

Peptide-block-polymer copolymers possess a monodisperse peptide segment with a freely programmable monomer sequence. An overview on the possibilities that arise from these precisely adjustable, functional polymers is presented.


http://onlinelibrary.wiley.com/doi/10.1002/marc.201000646/abstract
 
17.12.2010 - Single-step Electrospinning of Bioactive Polymer Nanofibers
Polymer nanofiber meshes that possess biofunctional peptide segments on their surfaces are obtained with a standard electrospinning setup. Spinning a homogeneous mixture composed of a valuable polymer-peptide conjugate and a biocompatible commodity poly(ester) leads to nonwovens where the peptide part is enriched up to 11-times on the fiber surface. Bioavailability and bioactivity of the peptides are demonstrated as the meshes promote adhesion and migration of fibroblasts.  
15.12.2010 - Merry X-mas - Wir wünschen allen frohe Weihnachten & ein erfolgreiches Jahr 2011!

@ Potsdam Weihnachtsmarkt

@ Happy Sumo Weihnachts-Sushi
17.11.2010 - Christian Stutz in den Bundesvorstand des JungChemikerForums gewählt
Christian Stutz vom Arbeitskreis Prof. Hans Börner der Humboldt-Universität zu Berlin wurde beim diesjährigen Sprechertreffen der JungChemiker in Würzburg in den Bundesvorstand des JungChemikerForums der Gesellschaft Deutscher Chemiker gewählt. Sein Ressourcengebiet umfasst die Öffentlichkeitsarbeit und Homepage des Forums.
www.jungchemikerforum.de
22.10.2010 - Modular Approach toward Bioactive Fiber Meshes Carrying Oligosaccharides
In a single step, polymer nanofibers with pentafluorophenyl (Pfp) activated esters at the surface are fabricated by electrospinning of either pure poly(pentafluorophenyl methacrylate) (PPfpMA) or PPfpMA / poly(ε-caprolactone) (PCL) blends which can be successfully functionalized with amino-functional biomolecules like saccharides for immune response.
22.10.2010 - A modular approach towards functional decoration of peptide–polymer nanotapes
Self-assembled peptide–polymer nanotapes of poly(ethylene oxide)–peptide conjugates are modified by a simple amine–azide transfer to create azide-containing nanofibres, which provide a platform for modular functionalization as demonstrated by the introduction of different carboxyl bearing entities to modulate the calcium binding properties of the nanotapes.