Welcome to BörnerLab

Research Overview

  1. Synthesis and design of functional hybrid polymers (bioconjugates)
  2. Bio-mimetic formation of structure and function in synthetic polymers (peptide-guided organization and structure based functions)
  3. Pseudopeptides and precision polymers for biomedical applications (integrated polymer systems for gene or drug delivery)
  4. Bio-functionalization of surfaces (bioactive polymer fibers, scaffolds and material interfaces; Bio-inspired adhesion segments in block copolymers, (bio)-functional coatings, crystal growth modifiers)

Objectives: Controlling interactions in synthetic polymers as precisely as in proteins would have a strong impact on polymer science. Advanced structural and functional control can lead to rational design of, integrated nano- and microstructures. To achieve this, properties of oligopeptides were exploited. By incorporating these as monodisperse segments into synthetic polymers we show how to program structure formation in polymers, control inorganic-organic interfaces in fiber composites, induce structure in biomacromolecules for biomedical applications and generate bioactive surfaces to control biological systems.
 


News

17.06.2020 - Congratulations to Emmanuelle Schue
Today Emmanuelle Schue has defended his outstanding PhD theses „Oxidative intramolecular crosslinking in sequence-controlled polymers: Approaches toward more complex designs and folding analysis “.

Congratulations and good luck for your future career!

03.06.2020 - Congratulations to Matthias Röber!
Matthias Röber absolvierte die erste digitale Promotionsverteidigung im AK Börner und schloss damit seine Promotion zum Thema „Templatgeleitete Strukturbildung kollagenartiger Peptide" erfolgreich ab.

Wir gratulieren zum Doktortitel und zur Einstellung bei Pensatech Pharma GmbH.

 
12.03.2020 - Congratulations to Felix Gandor!
Today Felix Gandor has defended his outstanding PhD theses „Peptid-Polymer Kompatibilisatoren für bioinspirierte Verbundwerkstoffe”.

Congratulations and good luck for your future career!

18.02.2020 - Student internship in polymer chemistry
Today we welcomed students of the Gorge-Orwell-school from Berlin Lichtenberg for a laboratory internship in polymer chemistry.


27.11.2019 - Congratulations to Justus Horsch!
Today Justus Horsch has defended his outstanding PhD theses „Muschel-inspirierte Polymerisation: Synthetische Bioadhäsive für wasserbasierte Klebstoffe und meerwasserresistente Beschichtungen“ with “summa cum laude”.


Congratulations and good luck for your future career!
06.11.2019 - Mussel‐Inspired Polymerization of Peptides: The Chemical Activation Route as Key to Broaden the Sequential Space of Artificial Mussel‐Glue Proteins
New Paper released in Macromolecular Rapid Communications.

Background: A chemical activation route makes the use of tyrosinase in the mussel‐inspired polymerization of peptides obsolete and enables the exploitation of the sequence space to generate artificial mussel‐glue proteins. This is shown by polymerizing the minimal adsorption domain Dopa‐Lys‐Cys, leading to poly(Dopa‐Lys‐Cys) with non‐peptidic thiol–catechol connectivities in the backbone. Polymer films are formed under seawater conditions and resist washing with 4.2 M hypersaline solution.

Full article link: https://onlinelibrary.wiley.com/doi/full/10.1002/marc.201900431

22.07.2019 - Learning from peptides to access functional precision polymer sequences
New Paper in Angewandte Chemie has been published and is highlighted as hot article in drug delivery research:


 
Background: A new strategy to guide the sequence design for accessing functional precision polymers was described. For that purpose, a well-studied peptide that acts as a formulation additive to solubilize a photosensitizer drug was used and the direct translation of side chain functionality sequences towards precision polymer backbones, leads to macromolecules, which mimic drug hosting and release properties of the parent peptide.

Full article Link:

https://doi.org/10.1002/anie.201902217

Hot Topic: Drug Delivery:

https://onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1860-7187.hottopic-drugdelivery



17.07.2019 - ILLUMINATING BIONANO INTERFACES
11.06.2019 - Fish and Clips: A Convenient Strategy to Identify Tyrosinase Substrates with Rapid Activation Behavior for Materials Science Applications
New paper released in ACS Macro Letters:

Background: A Method for the identification of peptides with suitable substrate properties for the enzyme tyrosinase was developed by labeling of enzymatically activated solid-phase supported peptides in a one-bead-one-compound library with a fluorescent probe. This was achieved by Michael addition of a thiol-functionalized probe to dopaquinone residues resulting from enzymatic tyrosine oxidation. Activation kinetics of identified peptides verified the selection process and coating experiments underlined the applicability for materials science.

doi: 10.1021/acsmacrolett.9b00244


04.06.2019 - A strategy to better understand biological adhesion processes
The stick truth about mussel-glue inspired adhesive peptides at the nanomaterial interface


https://www.advancedsciencenews.com/the-sticky-truth-about-mussel-inspired-glue/
 
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