Group Members

Dr. Sebastian Wieczorek

Group of Prof. Börner
Department of Chemistry
Humboldt-Universität zu Berlin
Brook-Taylor-Str. 2, 12489 Berlin

Lab: 3'117
Phone: +49 (0)30 2093-7464
Sebastian Wieczorek

Curriculum Vitae

25.12.1982 born in Berlin, Germany
10/2005 - 03/2011 Chemistry studies (B.Sc./M.Sc.) at Freie Universität Berlin, Germany
02/2009 - 05/2009 Bachelor research thesis at Freie Universität Berlin under guidance of Prof. Dr. Koksch, „Analytical investigation on a-helical coiled coil forming beta- and gamma amino acid containing chimeras“
10/2010 - 01/2011
Master research thesis at Freie Universität Berlin under guidance of Prof. Dr. Koksch, „Selecting preferred interaction partners of homologated amino acids in a chimeric coiled coil motif: An application of phage display”
02/2011 - 04/2016
Doctoral research at Humboldt-Universität zu Berlin under guidance of Prof. Hans Börner, „Ein kombinatorischer Ansatz zur Entwicklung von spezifischen Löslichkeitsvermittlern für niedermolekulare Wirkstoffe“


1. S. Wieczorek, A. Dallmann, Z. Kochovski, H. G. Börner
„Advancing drug-formulation additives toward precision additives with release mediating peptide interlayer”
Journal of the American Chemical Society 2016, DOI: 10.1021/jacs.6b03604.
2. C. Lawatscheck, M. Pickhardt, S. Wieczorek, A. Grafmüller, E. Mandelkow, H. G. Börner, „Generalizing the concept of specific drug formulation additives toward non-fluorescent entities: A solubilization study on Alzheimer drugs”
Angewandte Chemie 2016, DOI: 10.1002/anie.201601147.
3. F. Zabihi, S. Wieczorek, M. Dimde, S. Hedtrich, H. G. Börner, R. Haag „Intradermal Drug Delivery by Nanogel-Peptide Conjugates; Specific and Efficient Transport of Temoporfin”
Journal of Controlled Release 2016, DOI:10.1016/j.jconrel.2016.07.033.
4. S. Wieczorek, S. Vigne, T. Masini, D. Ponader, L. Hartmann, A. K. H. Hirsch, H. G. Börner
„Combinatorial screening for specific drug transporters with switchable release profiles”
Macromolecular Bioscience 2015, 15, 82 – 89.
5. S. Wieczorek, T. Schwaar, M. O. Senge, H. G. Börner „Specific drug formulation additives: Revealing the impact of architecture and block length ratio”
Biomacromolecules 2015, 16 (10), 3308 – 3312.
6. M. Meißler, S. Wieczorek, N. ten Brummelhuis, H. G. Börner „Synthesis Aspects of Peptide- and Protein-Polymer Conjugates in the Pos-Click Era“
In Bio-inspired polymers; N. Bruns, A. F. M. Kilbinger, Eds.; Royal Society of Chemistry: London, UK, 2015, accepted.
7. N. ten Brummelhuis, S. Wieczorek, P. Wilke, T. Schwemmer, H. G. Börner
„Peptide-polymer conjugates as model systems to explore the functional space of precision polymers”
In Sequence-Controlled Polymers: Synthesis, Self-Assembly, and Properties; J. F. Lutz, T. Y. Meyer, M. Ouchi, M. Sawamoto, Eds.; ACS Symposium Serie 1170, American Chemical Society: Washington, DC, 2014; 55–69.
8. E. K. Nyakatura, R. R. Araghi, J. Mortier, S. Wieczorek, C. Baldauf, G. Wolber, B. Koksch
„An unusual interstrand H-bond stabilizes the hetero-assembly of helical αβγ-chimeras with natural peptides”
ACS Chemical Biology 2014, 9 (3), 613-616.
9. E. K. Nyakatura, J. Mortier, V. Radtke, S. Wieczorek, R. R. Araghi, C. Baldauf, G. Wolber, B. Koksch „β- and γ-Amino Acids at α-Helical Interfaces: Towards the Formation of Highly Stable Foldameric Coiled Coils”
ACS Medicinal Chemistry Letters 2014, 5 (12), 1300-1303.
10. S. Wieczorek, E. Krause, S. Hackbarth, B. Roeder, A. K. H. Hirsch, H. G. Börner „Exploiting specific interactions toward next-generation polymeric drug transporters”
Journal of the American Chemical Society 2013, 135 (5), 1711-1714.
11. R. R. Araghi, C. Jackel, H. Cölfen, M. Salwiczek, A. Völkel, S. C. Wagner, S. Wieczorek, C. Baldauf, B. Koksch „A β/γ Motif to Mimic α-Helical Turns in Proteins”
ChemBioChem 2010, 11, 335-339.