Welcome to BörnerLab

Research Overview

  1. Synthesis and design of functional hybrid polymers (bioconjugates)
  2. Bio-mimetic formation of structure and function in synthetic polymers (peptide-guided organization and structure based functions)
  3. Pseudopeptides and precision polymers for biomedical applications (integrated polymer systems for gene or drug delivery)
  4. Bio-functionalization of surfaces (bioactive polymer fibers, scaffolds and material interfaces; Bio-inspired adhesion segments in block copolymers, (bio)-functional coatings, crystal growth modifiers)

Objectives: Controlling interactions in synthetic polymers as precisely as in proteins would have a strong impact on polymer science. Advanced structural and functional control can lead to rational design of, integrated nano- and microstructures. To achieve this, properties of oligopeptides were exploited. By incorporating these as monodisperse segments into synthetic polymers we show how to program structure formation in polymers, control inorganic-organic interfaces in fiber composites, induce structure in biomacromolecules for biomedical applications and generate bioactive surfaces to control biological systems.
 


News

11.07.2018 - On the way to precision formulation additives: 2D-screening to select solubilizers with tailored host and release capabilities
New Paper in Journal of Controlled Release

 
Background: A 2-dimensional high-throughput screening method is presented to select peptide sequences from large peptide libraries for precision formulation additives, having a high capacity to specifically host a drug of interest and provide tailored drug release properties. The identified sequences are conjugated with poly(ethylene glycol) (PEG) to obtain peptide-PEG conjugates that proved to be valuable as solubilizers for small organic molecule drugs to overcome limitations of poor water-solubility and low bio-availability.

doi: 10.1016/j.jconrel.2018.06.032
29.11.2017 - Engineered collagen - a redox switchable framework for tunable assembly and fabrication of biocompatible surfaces
New Paper in ACS Biomaterials Science & Engineering has been published.
 
Background: Collagen, processed into several morphologies and originating from various sources, has long since been used as a biocompatible material that can assist wound healing and tissue regeneration. With the advent of biotechnology and solidphase peptide synthesis, new possibilities arise to create rationally designed biomaterials based on collagen sequences incorporating new functionalities whilst maintaining the beneficial properties of natural collagen. In this study a new class of synthetic collagen materials is presented, defined by its simplistic core structure and its therefore predictable behavior.

doi: 10.1021/acsbiomaterials.7b00583

16.11.2017 - PEGylated Precision Segments Based on Sequence-Defined Thiolactone Oligomers

New Paper in Macromolecular Rapid Communications has been published.

Background: A straightforward access route to multifunctional block copolymers, combining a poly(ethylene glycol) (PEG) block and a monodisperse segment with discrete monomer sequence based on thiolactone chemistry, is described. Exploiting an inverse conjugation strategy on a PEG preloaded poly(styrene) synthesis resin enables the convenient introduction of a predefined PEG-block at the α-terminus of thiolactone-based sequence-defined oligomers.

doi: 10.1002/marc.201700688

07.11.2017 - Identification of Functional Peptide Sequences to Lead the Design of Precision Polymers
New Review paper in Macromolecular Rapid Communications has been published.
Background: Peptide sciences developed dramatically as a result of routine use of solidphase peptide synthesis and nowadays offer a rich set of well-established strategies to design and identify functional peptide sequences for advanced applications in materials sciences. Appropriate sequences for a wide range of interesting material targets, ranging from molecules to materials surfaces and internal interfaces, can be selected via combinatorial means, and sequence specificities within the resulting peptide–target interactions can be routinely investigated. Based on this understanding, macromolecular sciences can define new polymer structures that meet required functionalities or functional sequences with fully synthetic, nonpeptidic precision polymers to endeavor toward information-based design of next-generation, purpose-adapted macromolecules.

doi: 10.1002/marc.201700632
15.03.2017 - Fine-tuning Nanocarriers Specifically toward Cargo: A Competitive Study on Solubilizing Related Photosensitizers for Photodynamic Therapy

New Paper in Bioconjugate Chemistry has been published.

Background: Tailor-made drug solubilizers are studied based on peptide-poly(ethylene glycol) conjugates, which exhibit peptide segments constituting binding motifs for the small-molecule drugs of interest to render them water-soluble. Suitable 7mer peptides are selected via combinatorial means by screening large one-bead-one-compound (OBOC) peptide libraries. The capability of the screening method to read out structural detail of the drugs is investigated by comparing three related photosensitizers (Chlorin E6 (Ce6), Pheophorbide A (Pba) and meta-tetra(hydroxyphenyl)chlorin (m-THPC), which are applicable for photodynamic cancer therapy.

doi: 10.1021/acs.bioconjchem.6b00549

03.01.2017 - Inhibition of Tau protein aggregation by rhodanine-based compounds solubilized via specific formulation additives to improve bioavailability and cell viability

New Paper in Current Alzheimer Research has been published.


Background: Anti-aggregation drugs play an important role in therapeutic approaches for Alzheimer’s disease. We have previously developed a number of compounds that are able to inhibit the pathological aggregation of Tau protein. One common obstacle to application is the limited penetration across the plasma membranes into cells, where Tau aggregation occurs in the cytosol. We used an inducible N2a cell line which expresses the repeat domain of tau and develops tau aggregates.
12.12.2016 - Easy access to triazolinedione-endcapped peptides for chemical ligation
New Paper in Chemical Communications has been published
A triazolinedione-precursor is directly built up from N-terminal peptide amine on resin enabling a versatile route towards peptide-polymer conjugates.
 

doi: 10.1039/c6cc08683g

06.12.2016 - SALSA Poster Session
CJ was rewarded the poster award of the SALSA Poster Session 2016. Congratulations!

The annual poster session of the School of Analytical Sciences Adlershof took place at the chemistry institute (Campus Adlershof) on December 6th, 2016. In the course of this event, CJ won a poster award. Congratulations! (link)
14.10.2016 - Chapter 1: Synthetic Aspects of Peptide- and Protein-Polymer Conjugates in the Post-click Era.

New book chapter in RSC Polymer Chemistry Series No. 22: Bio-inspired Polymers has been published.


 
 
This book chapter will provide an insight into the chemical synthesis of peptide- and protein-polymer conjugates, ranging from classical synthetic reactions, to efficient bioorthogonal strategies, novel bioconjugation techniques and chemoenzymatic approaches. Against the background of bio-inspiration, the book will give a comprehensive review of novel polymer synthesis, adaptive composites and bio-mimetic surfaces. Diverse applications of bio-inspired polymers in fields such as tissue engineering, drug delivery, optical materials and many more are described.

 
doi: 10.1039/9781782626664-00001

01.08.2016 - Advancing Drug Formulation Additives toward Precision Additives with Release Mediating Peptide Interlayer

New Paper in Journal of the American Chemical Society has been published


 

doi: 10.1021/jacs.6b03604

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