Welcome to BörnerLab

Research Overview

  1. Synthesis and design of functional hybrid polymers (bioconjugates)
  2. Bio-mimetic formation of structure and function in synthetic polymers (peptide-guided organization and structure based functions)
  3. Pseudopeptides and precision polymers for biomedical applications (integrated polymer systems for gene or drug delivery)
  4. Bio-functionalization of surfaces (bioactive polymer fibers, scaffolds and material interfaces; Bio-inspired adhesion segments in block copolymers, (bio)-functional coatings, crystal growth modifiers)

Objectives: Controlling interactions in synthetic polymers as precisely as in proteins would have a strong impact on polymer science. Advanced structural and functional control can lead to rational design of, integrated nano- and microstructures. To achieve this, properties of oligopeptides were exploited. By incorporating these as monodisperse segments into synthetic polymers we show how to program structure formation in polymers, control inorganic-organic interfaces in fiber composites, induce structure in biomacromolecules for biomedical applications and generate bioactive surfaces to control biological systems.
 


News

03.01.2017 - Inhibition of Tau protein aggregation by rhodanine-based compounds solubilized via specific formulation additives to improve bioavailability and cell viability

New Paper in Current Alzheimer Research has been published.


Background: Anti-aggregation drugs play an important role in therapeutic approaches for Alzheimer’s disease. We have previously developed a number of compounds that are able to inhibit the pathological aggregation of Tau protein. One common obstacle to application is the limited penetration across the plasma membranes into cells, where Tau aggregation occurs in the cytosol. We used an inducible N2a cell line which expresses the repeat domain of tau and develops tau aggregates.
12.12.2016 - Easy access to triazolinedione-endcapped peptides for chemical ligation
New Paper in Chemical Communications has been published
A triazolinedione-precursor is directly built up from N-terminal peptide amine on resin enabling a versatile route towards peptide-polymer conjugates.
 

doi: 10.1039/c6cc08683g

06.12.2016 - SALSA Poster Session
Carmen Juds was rewarded the poster award of the SALSA Poster Session 2016. Congratulations!

The annual poster session of the School of Analytical Sciences Adlershof took place at the chemistry institute (Campus Adlershof) on December 6th, 2016. In the course of this event, Mrs. Carmen Juds won a poster award. Congratulations! (link)
14.10.2016 - Chapter 1: Synthetic Aspects of Peptide- and Protein-Polymer Conjugates in the Post-click Era.

New book chapter in RSC Polymer Chemistry Series No. 22: Bio-inspired Polymers has been published.


 
 
This book chapter will provide an insight into the chemical synthesis of peptide- and protein-polymer conjugates, ranging from classical synthetic reactions, to efficient bioorthogonal strategies, novel bioconjugation techniques and chemoenzymatic approaches. Against the background of bio-inspiration, the book will give a comprehensive review of novel polymer synthesis, adaptive composites and bio-mimetic surfaces. Diverse applications of bio-inspired polymers in fields such as tissue engineering, drug delivery, optical materials and many more are described.

 
doi: 10.1039/9781782626664-00001

01.08.2016 - Advancing Drug Formulation Additives toward Precision Additives with Release Mediating Peptide Interlayer

New Paper in Journal of the American Chemical Society has been published


 

doi: 10.1021/jacs.6b03604

04.06.2016 - Easy Access toward Functional Patterns on Cellulose Paper by Combining Laser Printing and Material-Specific Peptide Adsorption

New Paper in Angewandte Chemie has been published

 
Stick to print: Selective coating of laser-printed patterns was achieved by material-specific adhesion of peptides to cellulose or toner. The peptide sequences were obtained using phage display. Functionalization of the immobilized peptides was realized by selective modification of tyrosine residues present on the printed-pattern coatings, offering new ways towards low-cost printed devices.

doi: 10.1002/anie.201601603
19.04.2016 - Enzyme-triggered antifouling coatings: switching bioconjugate adsorption via proteolytically cleavable interfering domains.

New paper in ACS Macro Letters has been published.


 

The enzymatic activation of non-adhesive peptide-polymer conjugates by proteoytic cleavage of suitable interfering domains results in stable surface coatings. An efficient reduction of protein/surface interactions is shown.

doi: 10.1021/acsmacrolett.6b00072
 

12.06.2015 - 4th International Conference

Felix Hanßke was rewarded a poster award. Congratulations!

From June 10 to 12, 2015 The 4th International Conference "Strategies in Tissue Engineering" of WITE e.V. took place at the Congress Center Würzburg. In the course of this event, Mr. Felix Hanßke won the poster award for the best “materials” poster. Congratulations! (link)
 

08.06.2015 - Generic biocombinatorial strategy to select tailor-made stabilizers for sol-gel nanoparticle synthesis.
New Paper in Small has been published.
 
A generic route toward de novo design of tailor-made stabilizers for sol-gel nanoparticle synthesis is described. By exploiting phage display biopanning to select stabilizers from large peptide libraries, a significantly larger chemical space (~ 109 different compounds) is explored, compared to commonly used knowledge-based or empiric strategies. The approach is demonstrated on the fluorolytic sol-gel synthesis of MgF2 nanoparticles from Mg(OCH3)2 precursors. Peptide sequences are selected, showing sequence-specific adsorption onto MgF2 particle surfaces.

doi: 10.1002/smll.201500162
 
05.05.2015 - School of Analytical Sciences Adlershof (SALSA) Poster Session 2015

Valeria Samsoninkova was rewarded the SALSA “Best Design” Poster award 2015. Congratulations! (link)
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