Welcome to BörnerLab

Research Overview

  1. Synthesis and design of functional hybrid polymers (bioconjugates)
  2. Bio-mimetic formation of structure and function in synthetic polymers (peptide-guided organization and structure based functions)
  3. Pseudopeptides and precision polymers for biomedical applications (integrated polymer systems for gene or drug delivery)
  4. Bio-functionalization of surfaces (bioactive polymer fibers, scaffolds and material interfaces; Bio-inspired adhesion segments in block copolymers, (bio)-functional coatings, crystal growth modifiers)

Objectives: Controlling interactions in synthetic polymers as precisely as in proteins would have a strong impact on polymer science. Advanced structural and functional control can lead to rational design of, integrated nano- and microstructures. To achieve this, properties of oligopeptides were exploited. By incorporating these as monodisperse segments into synthetic polymers we show how to program structure formation in polymers, control inorganic-organic interfaces in fiber composites, induce structure in biomacromolecules for biomedical applications and generate bioactive surfaces to control biological systems.


01.08.2016 - Advancing Drug Formulation Additives toward Precision Additives with Release Mediating Peptide Interlayer

New Paper in Journal of the American Chemical Society has been published


doi: 10.1021/jacs.6b03604

04.06.2016 - Easy Access toward Functional Patterns on Cellulose Paper by Combining Laser Printing and Material-Specific Peptide Adsorption

New Paper in Angewandte Chemie has been published

Stick to print: Selective coating of laser-printed patterns was achieved by material-specific adhesion of peptides to cellulose or toner. The peptide sequences were obtained using phage display. Functionalization of the immobilized peptides was realized by selective modification of tyrosine residues present on the printed-pattern coatings, offering new ways towards low-cost printed devices.

doi: 10.1002/anie.201601603
12.06.2015 - 4th International Conference

Felix Hanßke was rewarded a poster award. Congratulations!

From June 10 to 12, 2015 The 4th International Conference "Strategies in Tissue Engineering" of WITE e.V. took place at the Congress Center Würzburg. In the course of this event, Mr. Felix Hanßke won the poster award for the best “materials” poster. Congratulations! (link)

08.06.2015 - Generic biocombinatorial strategy to select tailor-made stabilizers for sol-gel nanoparticle synthesis.
New Paper in Small has been published.
A generic route toward de novo design of tailor-made stabilizers for sol-gel nanoparticle synthesis is described. By exploiting phage display biopanning to select stabilizers from large peptide libraries, a significantly larger chemical space (~ 109 different compounds) is explored, compared to commonly used knowledge-based or empiric strategies. The approach is demonstrated on the fluorolytic sol-gel synthesis of MgF2 nanoparticles from Mg(OCH3)2 precursors. Peptide sequences are selected, showing sequence-specific adsorption onto MgF2 particle surfaces.

doi: 10.1002/smll.201500162
05.05.2015 - School of Analytical Sciences Adlershof (SALSA) Poster Session 2015

Valeria Samsoninkova was rewarded the SALSA “Best Design” Poster award 2015. Congratulations! (link)
09.04.2015 - 4. Berliner Chemie Symposium (BCS)

Felix Hanßke was rewarded the poster award of the BCS/EYCN Meeting 2015. Congratulations!

The 4rd Berliner Chemie Symposium (BCS) together with the annual European Young Chemists Network (EYCN) meeting took place at the Erwin Schrödinger Zentrum (Campus Adlershof) on April 9th, 2015. In the course of this event, Mr. Felix Hanßke won a poster award. Congratulations! (link)

19.03.2015 - Synthesis of conjugates combining macromolecular brushes and rigid macrocycles.

New Paper in Polymer has been published.
On the occasion of the 65th birthday of Krzysztof Matyjaszewski (Link) a synthesis route to a conjugate comprised of two macromolecular brushes and a central shape persistent macrocycle utilizing ATRP is presented. As a result of the properties of the combined structure elements a functional macromolecule is obtained that regulates accessibility to a central shape persistent macrocycle via reversible brush-coil transitions.

19.11.2014 - Forum Junge Spitzenforscher: New Materials - Award

Patrick Wilke received:

Innovation award 2014 from Humboldt Innovation in collaboration with Stiftung Industrieforschung for the presentation “Ein biokombinatorischer Ansatz zu aktivierbaren, muschelinspirierten Adhäsiven”.

01.09.2014 - A direct biocombinatorial strategy towards next generation, mussel-glue inspired saltwater adhesives.
New Paper in Journal of the American Chemical Society has been published.
Biological materials exhibit remarkable, purpose-adapted properties that provide source of inspiration for designing new materials to meet the requirements of future applications. For instance, marine mussels are able to attach to a broad spectrum of hard surfaces under hostile conditions. Controlling wet-adhesion of synthetic macromolecules by analogue processes promises to strongly impact materials sciences by offering advanced coatings, adhesives and glues.

01.09.2014 - Revealing the impact of poly(ethylene oxide) blocks on enzyme activable coatings from peptide-polymer conjugates
New Paper in European Polymer Journal has been published.
Peptide-polymer conjugates composed of a poly(ethylene oxide) (PEO) block and a precursor segment from mussel foot protein-1 (mefp-1) are enzymatically oxidized by tyrosinase. A functional transition from weak/reversible binders to strong/irreversible adsorption onto aluminum oxide surfaces is observed. To elucidate effects of PEO-block length on the enzyme activable formation of antifouling coatings on aluminum oxide surfaces, a set of mefp-1-block-PEO bioconjugates with PEO-block lengths of 850, 3200 and 5200 g/mol is synthesized and investigated.

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