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Implementing Zn2+ ion and pH-value control into artificial mussel glue proteins by abstracting a His-rich domain form preCollagen

New Paper released in Soft Matter.


Abstract: A His-rich domain of preCollagen-D found in byssal threads is derivatized with Cys and Dopa flanks to allow for mussel-inspired polymerization. Artificial mussel glue proteins are accessed that combine cysteinyldopa for adhesion with sequences for pH or Zn2+induced β-sheet formation. The artificial constructs show strong adsorption to Al2O3, the resulting coatings tolerate hypersaline conditions and cohesion is improved by activating the β-sheet formation, that enhances E-modulus up to 60%.

Full article link: https://doi.org/10.1039/D0SM02118K